Intralipid as a novel Autophagy Inducer Target for Neurotoxic Effects of Rotenone

Previous studies showed that augmentation of the autophagy-lysosome process may be beneficial for many neurodegenerative diseases including Parkinson's disease (PD), in which abnormal accumulation aggregated proteins and mitochondrial dysfunctions are considered as crucial pathogenesis. Recently, several have advocated neuroprotective effects intralipid models numerous diseases. In this study, seventy C57BL/6 mice divided into seven groups were used to evaluate autophagy enhancement using metformin through neurobehavioural, a histopathological immunohistochemical examination rotenone-exposed brain. The administrated rotenone (2.5 mg/kg intraperitoneally), (100 mg/kg/day orally) 20% (15 mL/kg intraperitoneal) daily 4 weeks. Intralipid significantly recovered damaged brain tissue alleviated rotenone-induced damage. Furthermore, co-administration against produced more therapeutic efficiency. exerted protection neuro-injuries some extent process. pharmacological induction by represent novel strategy disease-modifier